Director of Research
Research Unit “Dynamics of Host-Pathogen Interactions”
Institute Pasteur, Paris, France
Dr. Jost Enninga studied biochemistry at the University of Hannover and the Hannover Medical School in Hannover, Germany, and performed his PhD studies in the Laboratory of Cell Biology at the Rockefeller University (USA) and under the supervision of Guenter Blobel where he focused on the transport of biological macromolecules between cellular compartments using cell biological approaches. Afterwards, Jost wanted to apply his cell biological knowledge to the investigation of host-pathogen interactions. So in spring 2004 he came to the Institute Pasteur, Paris, to work with Guy Tran Van Nhieu and Philippe Sansonetti on the secretion of type III effectors from Gram negative bacteria. At the beginning of 2008, Jost went on searching for new adventures, so he started his own independent research team in the department of Cell Biology and Infection at the Institut Pasteur in Paris.
Besides his research, Jost is dedicated to scientific teaching having co-organized a sequence of hands-on imaging courses at the Institute Pasteur and abroad.
Jost Enninga’s long standing research interest has been to decipher the principles how intracellular pathogens subvert host pathways to establish their niches at cellular and molecular level. To achieve this, he has developed novel imaging technologies that can capture the host-pathogen cross talk at the single cell level at high spatiotemporal resolution.
His research team has identified how the molecular cascades in the host cell is exploited by a variety of bacteria, such as Shigella flexneri, Salmonella enterica and Mycobacterium tuberculosis to gain access to the host cytosol.
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